NewEast Biosciences
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Activation Assay Kits
Arf6 Arl1 Arl3
Cdc42 13 i
o s z
Rab11 Rab3 Rab35
Rab4A Rab5 Rab7
Rab5A Rab5B Rab5C
Rac1 Ran Rap1
RalA RalB Ras
RheB RhoA Sar1
Antibodies for GTP-bound G Proteins
Arf6 Arl1 Arl3
Cdc42 13 i
o s z
Rab11 Rab3 Rab35
Rab4A Rab5 Rab7
Ran Rac1 Ral
Rap1 Ras RheB
RhoA Sar1
cAMP/cGMP EIA Kits
without Acetylation
cAMP cGMP
Biomarkers
β-Actin β-Tubulin Albumin
Apo A1 BMP3 cAMP
cGMP CystatinC EYA2
Fascin GAPDH IDH1
Kim-1 MUC1 Orai1-L1
Orai1-L2 Ric-8A
Septin9 SLC7A5 SUMO-1
SUMO-2/3 TFF3
Vimentin Cystatin C EIA Kit
Transferrin Fascin EIA Kit
Polyclonal Antibodies
ApoA1 Arf1 Arf6
Bag1 Cdc42 Ch Cdc42
ERBB2 GRB7 12
13 i o
q s z
IDH1 IDH2 Orai1-L1
Orai1-L2 Sar1a Pan
Rab11 Rab12 Rab13
Rab14 Rab17 Rab18
Rab22 Rab25 Rab26
Rab28 Rab2A Rab30
Rab31 Rab35 Rab38
Rab39 Rab3C Rab3D
Rab41 Rab5 Rab5A
Rab5B Rab5C Rab6A
Rab9A Rab8A Rac1
Rac2 Ral RalA
RalB Ran RhoA
Ras RheB
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Publications:

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B-Raf(V600E)
1.  Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma
    Mod Pathol. 2013 Mar;26(3):414-20.
2.  Immunohistochemistry as a quick screening method for clinical detection of BRAF(V600E) mutation in melanoma patients
    Tumor Biology. June 2014, Volume 35, Issue 6, pp 5727-5733
3.  Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma
    human pathology. February 2015Volume 46, Issue 2, Pages 169–175
4.  BRAF V600E Mutation-Specific Antibody: A Review
    Seminars in Diagnostic Pathology
5.  A novel approach for the detection and genetic analysis of live melanoma circulating tumor cells
    PLoS One. 2015 Mar 25;10(3):e0123376. doi: 10.1371
6.  Utility of BRAF V600E immunohistochemistry expression pattern as a surrogate of BRAF mutation status in 154 patients with advanced melanoma
    Human Pathology. Available online 6 May 2015
7.  Concomitant High Expression of BRAFV600E, P-cadherin and cadherin 6 is Associated with High TNM Stage and Lymph Node Metastasis in Conventional Papillary Thyroid Carcinoma
    Clin Endocrinol (Oxf). 2015 Aug 18. doi: 10.1111
8.  Activation of Grm1 expression by inducible mutated B-RAF in vitro and in vivo
    2015
9.  Immunohistochemistry as a Reliable Method for Detection of BRAF-V600E Mutation in Melanoma: A Systematic Review and Meta-Analysis of Current Published Literature
    Journal of Surgical Research. Available online 23 April 2016
10.  BRAFV600E and NRASQ61L/Q61R mutation analysis in metastatic melanoma using immunohistochemistry: a study of 754 cases highlighting potential pitfalls and guidelines for interpretation and reporting.
    Histopathology. 2016 May 6. doi: 10.1111
B-Raf mAb
1.  Comparison of 2 monoclonal antibodies for immunohistochemical detection of BRAF V600E mutation in malignant melanoma, pulmonary carcinoma, gastrointestinal carcinoma, thyroid carcinoma, and gliomas
    human pathology. November 2013Volume 44, Issue 11, Pages 2563–2570
EGFR(L858R)
1.  Immunohistochemistry with a novel mutation-specific monoclonal antibody as a screening tool for the EGFR L858R mutational status in primary lung adenocarcinoma
    Tumor Biology. October 2014
IDH(R132H)
1.  Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas
    Brain Tumor Pathology. January 2015, Volume 32, Issue 1, pp 3-11
IDH2(R172K) & IDH2(R140Q)
1.  Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
    Nature 513, 110–114 (04 September 2014)
2.  Metabolomic comparison between cells overexpressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism
    Journal of Neurochemistry. Volume 132, Issue 2, pages 183–193, January 2015
Ras mutation
1.  Are all RAS mutations the same? Coexisting KRAS and NRAS mutations in a caecal adenocarcinoma and contiguous tubulovillous adenoma.
    J Clin Pathol. 2015 Apr 29. pii: jclinpath-2015-202969. doi: 10.1136
2.  DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model
    Gene Therapy 21, 888-896 (October 2014)
3.  Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model
    Citation: Molecular Therapy Nucleic Acids (2016) 5, e282; doi:10.1038
CAMP
1.  Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1
    Pflugers Arch. 2012 Feb;463(2):257-68
2.  Antiarrhythmic effect of prolonged morphine exposure is accompanied by altered myocardial adenylyl cyclase signaling in rats
    Pharmacol Rep. 2012;64(2):351-9
3.  Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid beta(1-42)
    Neuropharmacology. 2013 Apr;67:272-83
4.  Subendocardial Increase in Reactive Oxygen Species Production Affects Regional Contractile Function in Ischemic Heart Failure
    Antioxid Redox Signal. 2013 Mar 20;18(9):1009-20
5.  Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1
    Pflugers Arch. 2012 Feb;463(2):257-68
6.  Structural basis of anthrax edema factor neutralization by a neutralizing antibody
    Biochemical and Biophysical Research Communications Volume 417, Issue 1, 6 January 2012, Pages 324–329
7.  Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats
    Pflügers Archiv - European Journal of Physiology October 2013, Volume 465, Issue 10, pp 1477-1486
8.  Opposing HDAC4 nuclear fluxes due to phosphorylation by β adrenergic activated PKA or by activity or Epac activated CaMKII in skeletal muscle fibres
    The Journal of Physiology Volume 591, Issue 14, pages 3605–3623, July 2013
9.  Sex is a major determinant of neuronal dysfunction in Neurofibromatosis Type 1
    Annals of Neurology Volume 75, Issue 2, pages 309–316, February 2014
10.  cAMP–PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3–Orai1 complex
    Pflügers Archiv - European Journal of Physiology October 2014, Volume 466, Issue 10, pp 1921-1932
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Protocols
Protocol for IF FAQs
Antibodies for Mutated Oncogenes
Ret Abl
AKT1 ALK
ATM B-Raf
BRCA1 BRCA2
CTNNB1 CTCF
EGFR ERBB2
EML4-ALK FGFR1
GNAQ IDH1
IDH2 JAK2
MEK1 NFE2L2
NOTCH PIK3CA
RHEB Ras
TP53 SMAD4
STK11 SMO
KIT
For WB Only (FREE SAMPLE)
ALK (D1225N) BRAF (D594G)
ALK (R1275Q) EGFR (L858Q)
MEK1 (E203K) KIT (V560D)
KIT (K642E) KIT (H697Y)
PIK3CA (G1049S) PIK3CA (E542K)
PIK3CA (Q546R) PIK3CA (Q546P)
EGFR (E746-A750)del Β-catenin (A43V)
Monoclonal Antibodies
Arf1 Arf6 Arl1
Arl3 Bag1 Cdc42
FGFR1 GNAQ 12
13 14 i
o q s
z Rab3A Rab35
Rab5 Rab7 Rab11
Rac1 Rac3 Ran
Ral RalB Ras
RheB RhoA Sar1
NFE2L2 His-tag Vimentin
Purified Proteins
Arf1 Δ17 Arf6
Arf6 Δ12 Q67L Arl1 Q71L
Cdc42 G12V Cdc42 His6-tag
CST3 Fascin1
Gα13 Gαi1
Gαi2 Q205L Rab3A Q81L
Rab35 Q67L Rab4A Q67L
Rab5 Rab5 Q79L
Rab7 Rab7 Q67L
Rac RalB
Ran Ran Q69L
Ras Ras Q61L
RhoA Sar1a
EGFR protein, L858R
NFE2L2 Protein D29G mutant
NFE2L2 Protein D77V mutant
NFE2L2 Protein E79K mutant
NFE2L2 Protein E79Q mutant
NFE2L2 Protein L30F mutant
NFE2L2 Protein R34Q mutant
NFE2L2 Protein V32T mutant
more...