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LYAR Rabbit pAb

Anti-LYAR Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219364

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219364
Product Name:   Anti-LYAR Rabbit Polyclonal Antibody
Synonyms:   ZLYAR; ZC2HC2
UNIPROT ID:   Q9NX58 (Gene Accession – BC015796 )
Background:    Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5′-GGTTAT-3′ (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
Immunogen:    Fusion protein of human LYAR
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 1000-5000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 219364(LYAR Antibody) at a dilution of 1/140(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the fusion protein and then with 219364(Anti-LYAR Antibody) at dilution 1/140.

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using 219364(Anti-LYAR Antibody) at a dilution of 1/140.

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with fusion protein and then with D226550(Anti-LYAR Antibody) at dilution 1/140.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane: LOVO cell lysate;
Primary antibody: 219364(LYAR Antibody) at dilution 1/1000;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 1 minute
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