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HEXA Rabbit pAb

Anti-HEXA Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219394

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219394
Product Name:   Anti-HEXA Rabbit Polyclonal Antibody
Synonyms:   TSD
UNIPROT ID:   P06865 (Gene Accession – BC018927 )
Background:    This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Immunogen:    Fusion protein of human HEXA
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 500-2000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 219394(HEXA Antibody) at a dilution of 1/110(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the fusion protein and then with 219394(Anti-HEXA Antibody) at dilution 1/110.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane 1-2: Jurakt and Hela cell lysates;
Primary antibody: 219394(HEXA Antibody) at dilution 1/700;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 1 minute
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