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HACE1 Rabbit pAb

Anti-HACE1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220591

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220591
Product Name:   Anti-HACE1 Rabbit Polyclonal Antibody
Synonyms:   
UNIPROT ID:   Q8IYU2 (Gene Accession – NP_065822 )
Background:    HACE1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1), also known as KIAA1320, is a 909 amino acid protein that localizes to both the cytoplasm and the endoplasmic reticulum and contains one HECT domain and six ANK repeats. Expressed in kidney, heart and brain, HACE1 functions as an E3 ubiquitin-protein ligase that interacts with the proteasome and is thought to play a role in protein degradation. HACE1 is downregulated in Wilms tumor, suggesting a possible role in tumor suppression.
Immunogen:    Synthetic peptide of human HACE1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 220591(HACE1 Antibody) at a dilution of 1/50(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 220591(Anti-HACE1 Antibody) at dilution 1/50.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 220591(Anti-HACE1 Antibody) at a dilution of 1/50.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D261734(Anti-HACE1 Antibody) at dilution 1/50.
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