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INS(C-peptide) Rabbit pAb

Anti-INS(C-peptide) Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221632

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221632
Product Name:   Anti-INS(C-peptide) Rabbit Polyclonal Antibody
Synonyms:   IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
UNIPROT ID:   P01308 (Gene Accession – NP_000198 )
Background:    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5′ region and with the IGF2 gene at the 3′ region. Alternative splicing results in multiple transcript variants.
Immunogen:    Synthetic peptide of human INS(C-peptide)
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Metabolism, Neuroscience, Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 221632(INS(C-peptide) Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 221632(Anti-INS(Anti-C-peptide) Antibody) at dilution 1/40.
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