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Phospho-GSK3 (Tyr216/Tyr279) Rabbit mAb

Anti-Phospho-GSK3 (Tyr216/Tyr279) Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262306

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262306
Product Name:   Anti-Phospho-GSK3 (Tyr216/Tyr279) Rabbit Monoclonal Antibody
Synonyms:   Serine/threonine-protein kinase GSK3A; Serine/threonine-protein kinase GSK3B
UNIPROT ID:   P49840/P49841
Background:    Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Immunogen:    A synthetic phosphopeptide corresponding to residues surrounding Tyr216 of human GSK3 alpha
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R01-5G6
MW:    Calculated MW: 51 kDa; Observed MW: 47-51 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Mouse,Rat
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-GSK3 (alpha/beta) (Tyr216/Tyr279) in C6, 3T3 lysates using Phospho-GSK3 (Tyr216/Tyr279) antibody.
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