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Homer1 Rabbit mAb

Anti-Homer1 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262354

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262354
Product Name:   Anti-Homer1 Rabbit Monoclonal Antibody
Synonyms:   HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
UNIPROT ID:   Q86YM7
Background:    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines .
Immunogen:    Recombinant protein of human Homer1
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R01-5B7
MW:    Calculated MW: 40 kDa; Observed MW: 46 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Homer1 in rat Brain lysates using Homer1 antibody.

Western blot analysis of Homer1 in mouse brain lysates using Homer1 antibody.
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