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Phospho-Rb2 p130 (Ser952) Rabbit mAb

Anti-Phospho-Rb2 p130 (Ser952) Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262824

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262824
Product Name:   Anti-Phospho-Rb2 p130 (Ser952) Rabbit Monoclonal Antibody
Synonyms:   Rb2; P130
UNIPROT ID:   Q08999
Background:    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Immunogen:    A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130
Applications:    WB,IHC-F,IHC-P,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R02-5D6
MW:    Calculated MW: 128 kDa; Observed MW: 128 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunocytochemistry analysis of Rb2 p130 (Phospho-Ser952)(green) in Hela using Rb2 p130 (Phospho-Ser952) antibody,and DAPI(blue)

Western blot analysis of Rb2 p130 (Phospho-Ser952) in K562, Hela lysates using Phospho-Rb2 p130 (Ser952) antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Rb2 p130 (Phospho-Ser952) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
          Publications