NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$10.00 $0.00
Cat. #: 21012 |
Gene Symbol: GAPDH |
Description: Anti-GAPDH Rabbit Polyclonal Antibody |
Background: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate, an important energy-yielding step in carbohydrate metabolism. Additional functions of GAPDH include acting as a uricil DNA glycosylase, activating transcription, binding RNA and involvement in nuclear RNA export, DNA replication and DNA repair. Fuethermore, expression of GAPDH is upregulated in liver, lung and prostate cancers. Moreover, GAPDH complexes with neuronal proteins implicated in human neuro-degenerative disorders including the β-Amyloid precursor, Huntingtin and other triplet repeat neuronal disorder proteins. |
Immunogen: A synthetic peptide near the C-terminus of GAPDH of human origin |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA 1:100-1:5000 WB 1:100-1:2000 IHC 1:50-1:100 |
Concentration: 0.2 mg/ml |
Host Species: Rabbit |
Format: Liquid |
Clonality: Polyclonal |
Isotype: IgG |
Purity: Purified from serum |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Anti-GAPDH antibody recognizes GAPDH of vertebrates |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: EC-1 cell lysate was used for Western blot with Anti-GAPDH polyclonal antibody (Cat # 21012). |