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Antibodies for Active GTPase

GTPases are generally thought to be active when bound to GTP and inactive when bound to GDP, cycling between these two states regulated by two opposing protein families: guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). These are essential in dissociating tightly bound GDP from GTPases and promoting hydrolysis of GTP, respectively. Our Mouse Monoclonal Antibodies for GTP-bound G Proteins only recognize the active GTP-bound configuration, not inactive GDP-bound state. They have been used to monitor the activation of G protein in cells and in tissues by immunohistochemistry.
The RAS superfamily of small GTPases. The 153 members of the RAS superfamily have been classified into five families based on sequence identify and cellular functions (Wennerberg et al. 2005; Wittinghofer and Vetter 2011). Representative members of each family and the main cellular functions are shown.