Pioneering GTPase and Oncogene Product Development since 2010

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Antibodies for Active GTPase

GTPases are generally thought to be active when bound to GTP and inactive when bound to GDP, cycling between these two states regulated by two opposing protein families: guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). These are essential in dissociating tightly bound GDP from GTPases and promoting hydrolysis of GTP, respectively. Our Mouse Monoclonal Antibodies for GTP-bound G Proteins only recognize the active GTP-bound configuration, not inactive GDP-bound state. They have been used to monitor the activation of G protein in cells and in tissues by immunohistochemistry.