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Rab11-GTP

Anti-Rab11-GTP Mouse Monoclonal Antibody
5/5

$495.00

Cat.#:  26919

   Size:   30 μl

In Stock

            Product Description          

Rab11-GTP

Cat. #:   26919
Size:  30 µL
Gene Symbol:  RAB11
Description:   Anti-Rab11-GTP Mouse Monoclonal Antibody
Background:   Small GTPases of the Rab-family are crucial elements of the machinery that controls membrane traffic. Rab11 has been shown to control traffic through the recycling endosome.
Immunogen:   Recombinant full length protein of active Rab11
Applications:   IP, IHC and IF (Not applicable for WB since WB denatures the GTPase)
Recommended Dilutions:   
IP: 1 µg for 1~2 mg total cellular proteins
IHC, IF: 1:50-1:250
Concentration:   1 mg/ml
Host Species:   Mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:   IgG2b
Purity:    Purified from ascites
Preservative:  No
Constituents:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:  Anti-Rab11-GTP monoclonal antibody recognizes active Rab11 from vertebrates.
Storage Conditions:  Store at -20°C. Avoid repeated freezing and thawing
Immunoprecipitation/Western blot:  

Rab11 Activation Assay. Purified full-length Rab11 proteins were immunoprecipitated after treated with GDP (lane left) or GTPγS (lane right). Immunoprecipitation was done with the anti-Rab11-GTP monoclonal antibody (Cat. No. 26919). Immunoblot was with an anti-Rab5 polyclonal antibody (Cat. No. 21157).
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01. A novel homozygous variant in TRAPPC2L results in a neurodevelopmental disorder and disrupts TRAPP complex function
J Med Genet. 2021  PMID: 32843486

02. Effect of p18 on endothelial barrier function by mediating vascular endothelial Rab11a-VE-cadherin recycling
Biosci Biotechnol Biochem. 2021  PMID: 34747973

03. Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer
Cell Rep. 2021  PMID:  34348154

04. Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth
Signal Transduct Target Ther. 2020  PMID: 33033232

05. PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
Nat Commun. 2020  PMID: 31941925

06. Rab11 activation by Ik2 kinase is required for dendrite pruning in Drosophila sensory neurons
PLoS Genet. 2020  PMID: 32059017

07. RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation
J Cell Biol. 2019  PMID: 31201266

08. Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts
J Med Genet. 2018  PMID: 30120216

09. Impaired trafficking of β1 subunits inhibits BK channels in cerebral arteries of hypertensive rats
Hypertension. 2018  PMID: 30012867

10. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport
PLoS Pathog., 2017  PMID: 28945820

11. Endothelin-1 Stimulates Vasoconstriction Through Rab11A Serine 177 Phosphorylation
Circ Res., 2017  PMID: 28696251

12. Inactivation of Rab11a GTPase in macrophages facilitates phagocytosis of apoptotic neutrophils
J Immunol., 2017  PMID: 28053235

13. Membrane depolarization activates BK channels through ROCK-mediated ß1 subunit surface trafficking to limit vasoconstriction
Sci Signal., 2017  PMID: 28487419

14. Central role for PICALM in amyloid–ß blood–brain barrier transcytosis and clearance
Nat Neurosci. 2015  PMID: 26005850

15. Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors
Hepatology. 2015  PMID:  24917558

16. VASP promotes TGF-ß activation of hepatic stellate cells by regulating Rab11 dependent plasma membrane targeting of TGF-ß receptors
Hepatology. 2015  PMID: 24917558

17. Calcium dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel
Nat Cell Biol. 2014  PMID: 24335649

18. Ubiquitylation and activation of a Rab GTPase is promoted by a ß2AR-HACE1 complex
J Cell Sci. 2014  PMID: 24190883