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Rac-GTP

Anti-Rac1-GTP Monoclonal Antibody
5/5

$495.00

Cat.#:  26903

   Size:   30 μl

In Stock

            Product Description          
Rac1-GTP
Cat. #:  26903
Size:  30 µL
Gene Symbol:  RAC1
Description:   Anti-Rac1-GTP Monoclonal Antibody
Background:   Small GTPases are a super-family of cellular signaling regulators. Rac belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Rac, and the hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs).
Immunogen:   Recombinant full length protein of active Rac1
Applications:   IP, IHC and IF (Not applicable for WB since WB denatures the GTPase)
Recommended Dilutions:    IP: 1 µg for 1~2 mg total cellular proteins IHC, IF: 1:50-1:250
Concentration:   1 mg/ml
Host Species:   Mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:   IgM
Purity:   Purified from ascites
Preservative:  no
Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:  Anti-Rac1-GTP monoclonal antibody recognizes active Rac1 from vertebrates.
Storage Conditions:  Store at -20°C. Avoid repeated freezing and thawing
Immunoprecipitation/Western blot:   Rac Activation Assay. MEF cells were treated with (lane 2) or without (lane 1) PDGF. Cell lysates were incubated with an anti-Rac-GTP monoclonal antibody (Cat # 26903) (top panel). Th precipitated active Rac was immunoblotted with an anti-Rac rabbit polyclonal antibody (Cat # 21003). The bottom panel shows the Western blot with anti-Rac of the cell lysates used (5% of that used in the top panel).
Immunofluorescence:   Immunofluorescence for the active Rac using Anti-Rac1-GTP Mouse Monoclonal Antibody [26903] shows Rac-GTP immunolabeling (green) in combination with cofilin (red) on brain tissue sections. The tissue sections were fixed with -20 ºC methanol or 4% paraformaldehyde (fixation time 1 hr) and stained with antibody at 1:1000 in 0.1M Phosphate buffer with 0.3% Triton X, and 4% BSA for 24h at room temperature. Secondary antibodies were anti-mouse AlexaFluor488 and anti-rabbit AlexaFluor594 at 1:1000.
          Publications          
001. Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer
Exp Cell Res. 2023   PMID: 36584745
002. Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents
PLoS Pathog. 2023   PMID: 37115795
003. Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells
Int J Mol Sci. 2023   PMID: 37298689
004. Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation
Life Sci Alliance. 2022   PMID: 36446524
005. The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration
Life Sci Alliance. 2022   PMID: 36598812
006. Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons
J Cell Sci. 2023   PMID: 36744839
007. The Scaffold RhoGAP Protein ARHGAP8/ BPGAP1 Synchronizes Rac and Rho Signaling to Facilitate Cell Migration
Mol Biol Cell. 2023  PMID: 36598812
008. Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles
J Cell Commun Signal. 2022  PMID: 36508052
009. Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer
Exp Cell Res. 2022  PMID: 36584745
010. Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation
Life Sci Alliance. 2022  PMID: 36446524
011. Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles
J Cell Commun Signal. 2022  PMID: 36508052
012. Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine signaling
Mol Biol Cell. 2022  PMID: 35653297
013. Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice
Cell Death Discov. 2022  PMID: 35031595
014. Smooth muscle Rac1 contributes to pulmonary hypertension
BJP. 2022  PMID: 35064565
015. Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification
Cardiovasc Pathol. 2022  PMID: 35074515
016. A Portable Controllable Compressive Stress Device to Monitor Human Breast Cancer Cell Protrusions at Single-Cell Resolution
J Clin Invest. 2022  PMID: 35104805
017. Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition – More Than Just ROS-inhibition
J Clin Transl Hepatol. 2022  PMID: 35233372
018. Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension
J Neuroinflammation. 2022  PMID: 35284404
019. Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells
Development. 2022  PMID: 35420656
020. Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats
Front Mol Neurosci. 2022  PMID: 35782392
021. Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor
Front Bioeng Biotechnol. 2022  PMID: 35831873
022. ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42
J Exp Clin Cancer Res. 2022  PMID: 35869555
023. Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
Sci Adv. 2022  PMID:  36129975
024. Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation
Nat Commun. 2022  PMID:  36130971
025. The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner
Biomolecules. 2022  PMID: 36139020
026. Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage
Cell Death Dis. 2022  PMID: 36229446
027. Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis
J Cell Commun Signal. 2022  PMID: 36284029
028. PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate
Biomolecules. 2022  PMID: 36291720
029. Dock4 is required for the maintenance of cochlear hair cells and hearing function
Fundamental Research. 2022
030. A role of PIEZO1 in iron metabolism in mice and humans.
Cell. 2021  PMID: 33571427
031. A RAC-GEF network critical for early intestinal tumourigenesis
Nat Commun. 2021  PMID: 33397922
032. Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence
J Leukoc Biol. 2021  PMID: 33527537
033. Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling
Thorax. 2021  PMID: 33542087
034. 7-ketocholesterol induces endothelial-mesenchymal transition and promotes fibrosis: implications in neovascular age-related macular degeneration and treatment
Angiogenesis. 2021  PMID: 33646466
035.  Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress
Cell Rep. 2021  PMID: 33852856
036. Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres
Sci Rep. 2021  PMID: 33927296
037.  EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice
eLife. 2021  PMID: 33973520
038. MFG‐E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose‐Dependent Mediation of Actin Polymerization
J Am Heart Assoc. 2021  PMID: 34041925
039. Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve
Development. 2021  PMID: 34086041
040. Flexible Ultrasonic Patch for Accelerating Chronic Wound Healing
Adv Healthc Mater. 2021  PMID: 34212532
041. Deregulated Rac1 Activity in Neural Crest Controls Cell Proliferation, Migration and Differentiation During Midbrain Development
Front Cell Dev Biol. 2021  PMID: 34557485
042. Decoupling Tumor Cell Metastasis From Growth By Cellular Pilot Protein TNFAIP8
Oncogene. 2021  PMID: 34608264
043. Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells
Exp Cell Res. 2021  PMID: 34626585
044. Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw
Front Cell Dev Biol. 2021  PMID: 34805177
045. Collective durotaxis along a self-generated stiffness gradient in vivo
Nature. 2021  PMID: 34880503
046. Sustained Release of Gas6 via mPEG-PLGA Nanoparticles Enhances the Therapeutic Effects of MERTK Gene Therapy in RCS Rats
Front Med (Lausanne). 2021  PMID: 34970569
047. yk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages
Front Immunol. 2021  PMID: 35003083
048. Voltage‐dependent activation of Rac1 by Nav1.5 channels promotes cell migration
J Cell Physiol. 2020  PMID: 31612502
049. Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis
Neurobiol Dis. 2020  PMID: 31931138
050. Statins Disrupt Macrophage Rac1 Regulation Leading to Increased Atherosclerotic Plaque Calcification
Arterioscler Thromb Vasc Biol. 2020  PMID: 31996022
051. Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors
Front Mol Neurosci. 2020  PMID: 32038159
052. Glycolysis Independent Glucose Metabolism Distinguishes TE from ICM Fate During Mammalian Embryogenesis
Dev Cell. 2020  PMID: 32197068
053. Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
Nat Commun. 2020  PMID: 32246016
054. The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation
Sci Rep. 2020  PMID: 32313148
055. Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance
Breast Cancer. 2020  PMID: 32314182
056. Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression
Experimental Cell Research. 2020  PMID: 32320683
057. PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation
Int J Mol Sci. 2020  PMID: 32580367
058. The laminin-211-derived PPFEGCIWN motif accelerates wound reepithelialization and increases phospho-FAK-Tyr397 and Rac1-GTP levels in a rat excisional wound splinting model
J Tissue Eng Regen Med. 2020  PMID:  32592615
059. Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
eLife. 2020  PMID: 32705984
060. TIQGAP1 Causes Choroidal Neovascularization by Sustaining VEGFR2-mediated Rac1 Activation
Angiogenesis. 2020  PMID: 32783108
061. Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton
J Cell Sci. 2020  PMID: 32788232
062. Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells
Oncogene. 2019  PMID: 30659265
063. The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration
J Leukoc Biol. 2019  PMID: 30748033
064. Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82
Bone Reports. 2019  PMID: 30788390
065. Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis
Gynecol Oncol. 2019  PMID: 30797592
066. Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma
Cancer Res. 2019  PMID: 30833420
067. In vivo topology converts competition for cell-matrix adhesion into directional migration
Nat Commun. 2019  PMID: 30944331
068. Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling
Int J Mol Sci. 2019  PMID: 30866434
069. Cdc42 activation by endothelin regulates neural crest cell migration in the cardiac outflow tract
Dev Dyn. 2019  PMID:  31219639
070. TUFT1 Promotes Triple Negative Breast Cancer Metastasis. Stemness. and Chemoresistance by Up-Regulating the Rac1/β-Catenin Pathway
Front Oncol. 2019  PMID: 31338333
071. Simvastatin pretreatment ameliorates t-PA–induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats
Neuropsychiatr Dis Treat. 2019  PMID: 31410004
072. PTPσ inhibitors promote hematopoietic stem cell regeneration
Nature Communications. 2019  PMID: 31413255
073. Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway
J Food Sci. 2019  PMID: 31529802
074. TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1ab5ac1 pathway
Cancer Cell Int. 2019  PMID: 31572059
075. Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation
Cell Rep. 2019  PMID: 31644919
076. Interplay between …2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
Nat Commun. 2019  PMID: 31757963
077. Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness
J Allergy Clin Immunol. 2018  PMID: 29155102
078. COL1A1 promotes metastasis in colorectal cancer by regulating the WNT/PCP pathway
Mol Med Rep. 2018  PMID: 29393423
079. Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart
Cardiovasc Res. 2018  PMID: 29444209
080. p66Shc Regulates Migration of Castration-Resistant Prostate Cancer Cells
Cell Signal. 2018  PMID: 29462661
081. Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice
Cell Death Dis. 2018  PMID: 29497040
082. Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis
Dev Biol. 2018   PMID: 29580943
083. Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
Cancer Discov. 2018  PMID: 29581176
084. Complement C3 Affects Rac1 Activity in the Developing Brain
Front Mol Neurosci. 2018  PMID: 29867343
085. The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 + T cells
J Exp Med. 2018  PMID: 29875261
086. RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3
Laboratory Investigation. 2018  PMID: 29884911
087. Removing physiological motion from intravital and clinical functional imaging data
eLife. 2018  PMID: 29985127
088. Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease
Acta Neuropathol Commun. 2018  PMID: 30005699
089. MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling
Oncol Lett. 2018   PMID: 30008936
090. The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cells
Mol Biol Cell. 2018   PMID: 30133344
091. The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion
Oncogene. 2017  PMID: 27669437
092. Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model
J Dent Res. 2017  PMID: 27927890
093. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary
PLoS Genet. 2017  PMID: 28072828
094. Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma
Oncotarget. 2017  PMID: 28423558
095. Rac1 activation in podocytes induces the spectrum of nephrotic syndrome
Kidney Int. 2017  PMID: 28483380
096. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis
Dev Biol. 2017  PMID: 28552735
097. High glucose levels promote the proliferation of breast cancer cells through GTPases
Breast Cancer (Dove Med Press). 2017  PMID: 28670141
098. Role of Nicotinamide N-Methyltransferase in Dorsal Striatum in Cocaine Place Preference
Neuropsychopharmacology. 2017  PMID: 28726800
099. The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage
Blood. 2017  PMID: 28743719
100. Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function
Hum Mol Genet. 2017  PMID: 29016860
101. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2
Nature Immunology. 2017  PMID: 29058702
102. A PTEN-COL17A1 fusion gene and its novel regulatory role in Collagen XVII expression and GBM malignance
Oncotarget. 2017  PMID: 29156757
103. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery
eLife. 2017  PMID: 29271742
104. Disease-causing mutations of RhoGDIa induce Rac1 hyperactivation in podocytes
Small GTPases. 2016  PMID: 26726844
105. The acetylenic tricyclic bis(cyano enone). TBE-31. targets microtubule dynamics and cell polarity in migrating cells
Biochim Biophys Acta. 2016  PMID: 26775215
106. Dosage-dependent role of Rac1 in podocyte injury
Am J Physiol Renal Physiol. 2016  PMID: 26792065
107. Rac1/β-Catenin Signalling Pathway Contributes to Trophoblast Cell Invasion by Targeting Snail and MMP9.
Cell Physiol Biochem. 2016   PMID: 27008403
108. A Stromal Cell–Derived Factor 1a Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome
Mol Med. 2016  PMID: 27031787
109. The RacGAP protein FilGAP is a negative regulator of chemokine-promoted lymphocyte migration
FEBS Lett. 2016  PMID:  27130700
110. Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice
Eur J Immunol. 2016  PMID:  27188212
111. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear.
Neuropharmacology. 2016   PMID: 27329554
112. Zinc induces epithelial to mesenchymal transition in human lung cancer H460 cells via superoxide anion-dependent mechanism
Cancer Cell Int. 2016  PMID: 27330411
113. RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3
Oncogene. 2016   PMID: 27425596
114.  Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder.
Biofactors. 2016  PMID: 27452812
115. Sur8 mediates tumorigenesis and metastasis in colorectal cancer
Exp Mol Med. 2016  PMID: 27469030
116. The modulation of MiR-155 and MiR-23a manipulates Klebsiella pneumoniae Adhesion on Human pulmonary Epithelial cells via Integrin α5β1 Signaling
Sci Rep. 2016  PMID: 27534887
117. Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells
Evid Based Complement Alternat Med. 2016  PMID: 27651818
118. Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling
Am J Physiol Lung Cell Mol Physiol. 2016   PMID: 27765763
119. Converging. Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses
J Neurosci. 2016  PMID: 27807170
120. Rac signal adaptation controls neutrophil mobilization from the bone marrow
Sci Signal. 2016   PMID: 27999173
121. miRNA-17 members that target Bmpr2 influence signaling mechanisms important for embryonic stem cell differentiation in vitro and gastrulation in embryos
Stem Cells Dev. 2015  PMID: 25209090
122. LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix
Cancer Lett. 2015  PMID: 25451317
123. Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1
Cancer letters. 2015  PMID: 25529012
124. Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer
Clin Cancer Res. 2015  PMID: 25595279
125. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory
Mol Neurobiol. 2015  PMID: 25613020
126. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase
J Biol Chem. 2015  PMID: 25666619
127. Fibroblastic Transformation of Corneal Keratocytes by Rac Inhibition is Modulated by Extracellular Matrix Structure and Stiffness
J Funct Biomater. 2015  PMID: 25874856
128. Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation. reactive oxygen species production. and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway
BMC Complement Altern Med. 2015  PMID: 25886843
129. TIPE2 protein prevents injury-induced restenosis in mice
Biochim Biophys Acta. 2015  PMID: 25912734
130. Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens
Neurosci Lett. 2015  PMID: 25957559
131. A bibenzyl from Dendrobium ellipsophyllum inhibits migration in lung cancer cells
J Nat Med. 2015  PMID: 26109451
132. The cytohesin guanosine exchange factors (GEFs) are required to promote HGF-mediated renal recovery after acute kidney injury (AKI) in mice
Physiol Rep. 2015  PMID: 26116550
133. A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration
Nat Commun. 2015  PMID: 26166433
134. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice
Cell Death Differ. 2015  PMID: 26184908
135. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
Nat Commun. 2015  PMID: 26234763
136. Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2
Neuroscience. 2015.  PMID: 26299339
137. Rac1 Regulates Endometrial Secretory Function to Control Placental Development
PLoS Genet. 2015  PMID: 26305333
138. Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling
Oncotarget. 2015  PMID: 26384305
139. Rac1 augments Wnt signaling by stimulating beta-catenin-LEF-1 complex assembly independent of beta-catenin nuclear import
J Cell Sci. 2015  PMID: 26403202
140. Rap1 GTPase Inhibits Tumor Necrosis Factor-à-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-?B-Dependent Activation of Rac1
Am J Pathol. 2015  PMID: 26476350
141. Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve
Current Biology. 2015  PMID: 26725196
142. Immunofluorescence and Confocal Microscopy of Neutrophils
Methods Mol Biol. 2014  PMID: 18453118
143. Jak3 Enables Chemokine-Dependent Actin Cytoskeleton Reorganization by Regulating Cofilin and Rac/Rhoa GTPases activation
PLoS One. 2014  PMID: 24498424
144. High incidence of naevi-associated BRAF wild-type melanoma and dysplastic naevi under treatment with the class I BRAF inhibitor vemurafenib
Acta Derm Venereol. 2014  PMID: 24531394
145. A link between the nuclear-localized srGAP3 and the SWI/SNF chromatin remodeler Brg1
Molecular and Cellular Neuroscience. 2014  PMID: 24561795
146. Phosphorylation of α-tubulin by protein kinase C stimulates microtubule dynamics in human breast cells
Cytoskeleton. 2014  PMID: 24574051
147. SHP2 Phosphatase Promotes Mast Cell Chemotaxis toward Stem Cell Factor via Enhancing Activation of the Lyn/Vavac Signaling Axis
The Journal of Immunology. 2014  PMID: 24733849
148. ROBO1. a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: Study in African-American and Caucasian prostate cancer models
International Journal of Cancer. 2014  PMID: 24752651
149. Transcription factors NRF2 and nf-kb are coordinated effectors of the RHO family. GTP binding protein rac1 during inflammation
J Biol Chem. 2014   PMID: 24759106
150. PI(4.5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site
Development. 2014  PMID: 24821989
151. Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells
Int J Oncol. 2014  PMID: 24859471
152. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1
Asian Pac J Trop Med. 2014  PMID: 25149377
153. Canonical and Non-canonical G-protein Signaling Helps Coordinate Actin Dynamics to Promote Macrophage Phagocytosis of Zymosan
Mol Cell Biol. 2014   PMID: 25225330
154. p53 Down Regulates PDGF-Induced Formation of Circular Dorsal Ruffles in Rat Aortic Smooth Muscle Cells
PLoS One. 2014   PMID: 25247424
155. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1
J Clin Invest. 2014  PMID: 25295536
156. Triclosan Potentiates Epithelial-To-Mesenchymal Transition in Anoikis-Resistant Human Lung Cancer Cells
PLoS One. 2014  PMID: 25329306
157. cAMP controls the restoration of endothelial barrier function after thrombin‐induced hyperpermeability via Rac1 activation
Physiological Reports. 2014  PMID: 25344477
158. Cisplatin at Sub-toxic Levels Mediates Integrin Switch in Lung Cancer Cells
Anticancer Research. 2014  PMID: 25503138
159. Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter
Integr Biol (Camb). 2014  PMID: 25539497
160. Neuregulin Mediates F-actin-driven Cell Migration through Inhibition of Protein Kinase D1 via Rac1 Protein
J Biol Chem. 2013  PMID: 23148218
161. Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering beta-catenin transcriptional activity under high glucose conditions
Int J Biochem Cell Biol. 2013   PMID: 23153508
162. Reactive Oxygen Species Are Induced by Kaposi’s Sarcoma-Associated Herpesvirus Early during Primary Infection of Endothelial Cells To Promote Virus Entry
J Virol. 2013  PMID: 23175375
163. Essential Role of Class II Phosphatidylinositol-3-kinase-C2alpha in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells
J Biol Chem. 2013  PMID: 23192342
164. PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowt
J Cell Sci. 2013  PMID: 23321640
165. Deficiencies of the Lipid-Signaling Enzymes Phospholipase D1 and D2 Alter Cytoskeletal Organization. Macrophage Phagocytosis. and Cytokine-Stimulated Neutrophil Recruitment
PLoS One. 2013  PMID: 23383154
166. Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles
J Cardiovasc Pharmacol. 2013   PMID: 23429587
167. A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates
Autophagy. 2013  PMID: 23439251
168. Rac1 is required for matrix metalloproteinase-13 production by chondrocytes in response to fibronectin fragments
Arthritis Rheum. 2013  PMID: 23460186
169. Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization
Development. 2013  PMID: 23533177
170. Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Mol Cancer Res. 2013   PMID: 23699534
171. Pilus Phase Variation Switches Gonococcal Adherence to Invasion by Caveolin-1-Dependent Host Cell Signaling
PLoS Pathog. 2013  PMID: 23717204
172. ArhGAP15. a Rac-specific GTPase-activating Protein. Plays a Dual Role in Inhibiting Small GTPase Signaling
J Biol Chem. 2013  PMID: 23760270
173. Kalirin-7 Mediates Cocaine-Induced AMPA Receptor and Spine Plasticity. Enabling Incentive Sensitization
J Neurosci. 2013  PMID: 23825406
174. p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
PLoS One. 2013  PMID: 24019894
175. Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells
Cell Death Dis. 2013  PMID: 24113182
176. A directional switch of integrin signaling and a new anti-thrombotic strategy
Nature. 2013  PMID: 24162846
177. JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation
J Cell Biol. 2013  PMID: 24368807
178. he cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling
Cell Microbiol. 2012   PMID: 21999233
179. Interferon gamma induces actin polymerization. Rac1 activation and down regulates phagocytosis in human monocytic cells
Cytokine. 2012  PMID: 22137120
180. Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac
Am J Pathol. 2012  PMID: 22203054
181. Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions
J Cell Sci. 2012  PMID: 22349701
182. rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
Nat Neurosci. 2012  PMID: 22522400
183. Antagonistic activities of Rho and Rac GTPases underlie the transition from neural crest delamination to migration
Dev Dyn. 2012   PMID: 22553120
184. miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling
EMBO J. 2012  PMID:  22588079
185. Interferon-beta Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
Sci Signal. 2012  PMID: 22623753
186. Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva
Invest Ophthalmol Vis Sci. 2012   PMID: 22695959
187. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
J Cell Biol. 2012  PMID: 22891260
188. Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis
PLoS One. 2012  PMID: 22936985
189. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion
PLoS One. 2012  PMID: 23185572
190. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin
J Neurosci. 2012  PMID: 23197717
191. Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex
J Neurosci. 2012  PMID: 23223289
192. Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation
Am J Physiol Heart Circ Physiol. 2011   PMID: 21037229
193. K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity
PLoS One. 2011  PMID: 21358804
194. Asymmetric Mbc. active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila
Development. 2011  PMID: 21389053
195. Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism
ACS Nano. 2011  PMID: 21563770
196. R-Ras and Rac GTPase Cross-talk Regulates Hematopoietic Progenitor Cell Migration. Homing. and Mobilization
J Biol Chem. 2011  PMID: 21572048
197. Differential roles of Smad2 and Smad3 in the regulation of TGF-beta1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
Mol Cancer. 2011  PMID: 21624123
198. NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1
Cardiovasc Res. 2011  PMID: 21859816
199. Latent KSHV infection increases the vascular permeability of human endothelial cells
Blood. 2011   PMID: 21881052
200. Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype
J Cell Biol. 2011  PMID: 21893601
201. Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I
Int J Cell Biol. 2011  PMID: 21961005
202. Ethanol increases p190RhoGAP activity. leading to actin cytoskeleton rearrangements
J Neurochem. 2011  PMID: 21985251
203. Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis
J Leukoc Biol. 2010  PMID: 20610796
204. Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells
FEBS Lett. 2010  PMID: 20621840
205. Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells
J Periodontol. 2010  PMID: 20636139
206. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome
J Neurosci. 2010  PMID: 20720104
207. SUMOylation of the GTPase Rac1 is required for optimal cell migration
Nat Cell Biol. 2010  PMID: 20935639