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Mouse TREM2 Protein, hFc Tag

Recombinant mouse TREM2 protein with C-terminal human Fc tag
5/5

$389.00

Cat.#:  12202

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     12202
Product Name:   Mouse TREM2 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   TREM-2;Trem2a;Trem2b;Trem2c
Target:    TREM2
UNIPROT ID:    Q99NH8
Description:    Recombinant mouse TREM2 protein with C-terminal human Fc tag
Background:     The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 42.9 kDa after removal of the signal peptide.
Molecular Characterization:    Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Mouse TREM2 Protein, hFc Tag on SDS-PAGE under reducing condition.
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