NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$219.00
Bag1 Polyclonal Antibody
Cat. #: 21231 |
Gene Symbol: BAG1 |
Description: Anti-Bag1 Rabbit Polyclonal Antibody |
Background: BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene. It binds to oncogene BCL2, by which enhances the anti apoptotic effects of BCL2 and represents a link between growth factor receptors and anti apoptotic mechanisms. BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer’s. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively. |
Immunogen: A synthetic peptide from the central region of Bag1 protein, human origin. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA: 1:500-1:5000 WB: 1:200-1:2000 IHC: 1:20-1:200 |
Concentration: 0.2 mg/ml |
Host Species: Rabbit |
Format: Liquid |
Clonality: Polyclonal |
Isotype: IgG |
Purity: Purified from serum |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Anti-Bag1 rabbit polyclonal antibody recognizes Bag1 from vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing. |
Western blot: Purified full length His-tagged Bag1 protein was blotted with Anti-Bag1 rabbit polyclonal antibody (Cat. #21231). |