NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$239.00
Ric-8A
Cat. #: 26071 |
Gene Symbol: RIC8A |
Description: Anti-Ric8A Mouse Monoclonal Antibody |
Background: Ric-8A (Resistance to Inhibitors of Cholinesterase-8A) interacts with Gαo, Gαi, Gαq and Gα13, but not Gαs, proteins. Mammalian Ric-8A protein is a guanine nucleotide exchange factor for Gαq, Gαi, Gαo, Gα12, Gα13, but not for Gαs. C. elegans Ric8 (also named Synembryn) is required for proper asymmetric division of 1-cell-stage embryos. Ric8 is required for the generation of substantial pulling forces on astral microtubules. |
Immunogen: A synthetic peptide near the C-terminus of Ric-8A, human origin. |
Applications: ELISA, WB, IHC, IP |
Recommended Dilutions: ELISA: 1:100-1:5000 WB: 1:100-1:2000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Ric-8A antibody recognizes Ric-8A from vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Western blot analysis of Ric-8A proteins. Whole-cell lysate of HeLa cells was blotted with anti Ric-8A monoclonal antibody (Cat. #26071). |
01. Atypical Protein Kinase Cλ Is Critical for Growth Factor Receptor-induced Dorsal Ruffle Turnover and Cell Migration J Biol Chem. 2013 PMID: 24092753 |