NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$219.00
Ran Polyclonal Antibody
Cat. #: 21097 |
Gene Symbol: RAN |
Description: Anti-Ran Rabbit Polyclonal Antibody |
Background: Ran (Ras-related nuclear protein) is a member of the Ras-superfamily GTPases. Ran is invovled in the transport of proteins across the nuclear envelope, as well as in microtubule organization during mitosis. |
Immunogen: A synthetic peptide from the C-terminal region of human Ran |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA 1:100-1:5000 WB 1:100-1:2000 IHC 1:100-1:1000 |
Concentration: 0.2 mg/ml |
Host Species: Rabbit |
Format: Liquid |
Clonality: Polyclonal |
Isotype: IgG |
Purity: Purified from serum |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Anti-Ran antibody recognizes Ran of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Western blot analysis of Ran proteins. Whole-cell lysate of HepG2 cells was used for western blots with the polyclonal anti Ran antibody (Cat # 21097). |
1. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3 Nucleic Acids Res. 2012 Sep 1;40(17):8484-98 |