NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$445.00
Cat.#: 28511 |
Product Name: Anti-MICB(DM168) Rabbit Monoclonal Antibody |
Synonyms: MIC-B; PERB11.2 |
Description: Anti-MICB antibody(DM168) Rabbit Monoclonal Antibody |
Background: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells; CD8 alphabeta T cells; and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however; it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. |
Applications: ELISA; Flow Cyt |
Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100 |
Host Species: Rabbit |
Isotype: Rabbit IgG |
Purification: Purified from cell culture supernatant by affinity chromatography |
Species Reactivity: Human MICB |
Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. MICB protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-MICB (DM168) on Expi293 cells transfected with human MICB (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram). |