NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$445.00
Cat.#: 28508 |
Product Name: Anti-CLEC12A(DM165) Rabbit Monoclonal Antibody |
Synonyms: CLEC12A;MICL;CLL-1;CLL1;DCAL2;DCAL-2;CD371 |
Description: Anti-CLEC12A antibody(DM165) Rabbit Monoclonal Antibody |
Background: This gene encodes a member of the C-type lectin:C-type lectin-like domain (CTL:CTLD) superfamily. Members of this family share a common protein fold and have diverse functions; such as cell adhesion; cell-cell signaling; glycoprotein turnover; and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described; but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL:CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. |
Applications: ELISA; Flow Cyt |
Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100 |
Host Species: Rabbit |
Isotype: Rabbit IgG |
Purification: Purified from cell culture supernatant by affinity chromatography |
Species Reactivity: Human CLEC12A |
Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. Flow cytometry analysis with Anti-CLEC12A (DM165) on Expi293 cells transfected with human CLEC12A (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram). |