NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$445.00
Cat.#: 28231 |
Product Name: Anti-CXCR7(DMC443) IgG1 Chimeric Monoclonal Antibody |
Synonyms: Atypical chemokine receptor 3;CXC-R7;CXCR-7;Chemokine orphan receptor 1;G-protein coupled receptor 159;RDC-1 |
Description: Anti-CXCR7 antibody(DMC443) IgG1 Chimeric Monoclonal Antibody |
Background: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP); it is now considered to be an orphan receptor; in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. |
Applications: Flow Cyt |
Recommended Dilutions: Flow Cyt 1:100 |
Host Species: Rabbit |
Isotype: Rabbit:Human Fc chimeric IgG1 |
Purification: Purified from cell culture supernatant by affinity chromatography |
Species Reactivity: Human CXCR7 |
Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. Flow cytometry analysis with Anti-CXCR7 (DMC443) on Expi293 cells transfected with human CXCR7 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram). |