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RB1 Rabbit pAb

Anti-RB1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S210496

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S210496
Product Name:   Anti-RB1 Rabbit Polyclonal Antibody
Synonyms:   RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1
UNIPROT ID:   P06400 (Gene Accession – BC039060 )
Background:    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Immunogen:    Fusion protein of human RB1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 210496(RB1 Antibody) at a dilution of 1/90(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 210496(Anti-RB1 Antibody) at dilution 1/90.
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