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LRPAP1 Rabbit pAb

Anti-LRPAP1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S213641

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S213641
Product Name:   Anti-LRPAP1 Rabbit Polyclonal Antibody
Synonyms:   RAP, MRAP, A2RAP, HBP44, A2MRAP
UNIPROT ID:   P30533 (Gene Accession – NP_002328 )
Background:    Low density lipoprotein receptor-related protein associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which in humans is encoded by the LRPAP1 gene. LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.
Immunogen:    Synthetic peptide of human LRPAP1
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 500-2000;ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Metabolism, Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 213641(LRPAP1 Antibody) at a dilution of 1/100(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 213641(Anti-LRPAP1 Antibody) at dilution 1/100.

Gel: 10%SDS-PAGE, Lysate: 40 μg;
Lane 1-2: 293T cells, Human fetal kidney tissue;
Primary antibody: 213641(LRPAP1 Antibody) at dilution 1/1600;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 2 minutes
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