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CHRFAM7A Rabbit pAb

Anti-CHRFAM7A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S213677

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S213677
Product Name:   Anti-CHRFAM7A Rabbit Polyclonal Antibody
Synonyms:   D-10; CHRNA7; NACHRA7; CHRNA7-DR1
UNIPROT ID:   Q494W8 (Gene Accession – NP_683709 )
Background:    The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.
Immunogen:    Synthetic peptide of human CHRFAM7A
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 25-100;WB: 500-2000;ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer, Cardiovascular, Metabolism, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 213677(CHRFAM7A Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 213677(Anti-CHRFAM7A Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 213677(Anti-CHRFAM7A Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with synthetic peptide and then with D160647(Anti-CHRFAM7A Antibody) at dilution 1/40.

Gel: 10%SDS-PAGE, Lysate: 40 μg;
Lane: Mouse heart tissue;
Primary antibody: 213677(CHRFAM7A Antibody) at dilution 1/700;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 2 minutes
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