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SLC8A2 Rabbit pAb

Anti-SLC8A2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S213892

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S213892
Product Name:   Anti-SLC8A2 Rabbit Polyclonal Antibody
Synonyms:   NCX2
UNIPROT ID:   Q9UPR5 (Gene Accession – NP_055878 )
Background:    Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.
Immunogen:    Synthetic peptide of human SLC8A2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 213892(SLC8A2 Antibody) at a dilution of 1/15(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 213892(Anti-SLC8A2 Antibody) at dilution 1/15.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 213892(Anti-SLC8A2 Antibody) at a dilution of 1/15.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D161018(Anti-SLC8A2 Antibody) at dilution 1/15.
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