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CYP2C19 Rabbit pAb

Anti-CYP2C19 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S215641

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S215641
Product Name:   Anti-CYP2C19 Rabbit Polyclonal Antibody
Synonyms:   CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
UNIPROT ID:   P33261 (Gene Accession – NP_000760 )
Background:    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Immunogen:    Synthetic peptide of human CYP2C19
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 215641(CYP2C19 Antibody) at a dilution of 1/25(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 215641(Anti-CYP2C19 Antibody) at dilution 1/25.
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