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DROSHA Rabbit pAb

Anti-DROSHA Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S215687

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S215687
Product Name:   Anti-DROSHA Rabbit Polyclonal Antibody
Synonyms:   RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976
UNIPROT ID:   Q9NRR4 (Gene Accession – NP_037367 )
Background:    This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein comple,x which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
Immunogen:    Synthetic peptide of human DROSHA
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 215687(DROSHA Antibody) at a dilution of 1/45(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 215687(Anti-DROSHA Antibody) at dilution 1/45.
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