Email: info@neweastbio.com   |  Call: 6109452007

COX10 Rabbit pAb

Anti-COX10 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216275

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216275
Product Name:   Anti-COX10 Rabbit Polyclonal Antibody
Synonyms:   
UNIPROT ID:   Q12887 (Gene Accession – BC000060 )
Background:    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
Immunogen:    Fusion protein of human COX10
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 500-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human renal cancer tissue using 216275(COX10 Antibody) at a dilution of 1/100(Cytoplasm).
          Publications