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DDB2 Rabbit pAb

Anti-DDB2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216469

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216469
Product Name:   Anti-DDB2 Rabbit Polyclonal Antibody
Synonyms:   XPE; DDBB; UV-DDB2
UNIPROT ID:   Q92466 (Gene Accession – BC000093 )
Background:    This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen:    Fusion protein of human DDB2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer tissue using 216469(DDB2 Antibody) at a dilution of 1/30(Nucleus).

Immunohistochemistry analysis of paraffin-embedded Human colorectal cancer tissue using 216469(Anti-DDB2 Antibody) at a dilution of 1/30.
          Publications