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MLLT3 Rabbit pAb

Anti-MLLT3 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216953

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216953
Product Name:   Anti-MLLT3 Rabbit Polyclonal Antibody
Synonyms:   AF9; YEATS3
UNIPROT ID:   P42568 (Gene Accession – BC036089 )
Background:    Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at ‘Lys-9’ (H3K9cr), and with slightly lower affinity histone H3 crotonylated at ‘Lys-18’ (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at ‘Lys-9’ (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC comple,x MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).
Immunogen:    Fusion protein of human MLLT3
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 150-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 216953(MLLT3 Antibody) at a dilution of 1/155(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the fusion protein and then with 216953(Anti-MLLT3 Antibody) at dilution 1/155.
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