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DHCR7 Rabbit pAb

Anti-DHCR7 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217361

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217361
Product Name:   Anti-DHCR7 Rabbit Polyclonal Antibody
Synonyms:   SLOS
UNIPROT ID:   Q9UBM7 (Gene Accession – BC000054 )
Background:    This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
Immunogen:    Fusion protein of human DHCR7
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism, Cancer, Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 217361(DHCR7 Antibody) at a dilution of 1/75(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 217361(Anti-DHCR7 Antibody) at dilution 1/75.

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 217361(Anti-DHCR7 Antibody) at a dilution of 1/75.

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with fusion protein and then with D222232(Anti-DHCR7 Antibody) at dilution 1/75.
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