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HYAL2 Rabbit pAb

Anti-HYAL2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217524

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217524
Product Name:   Anti-HYAL2 Rabbit Polyclonal Antibody
Synonyms:   LUCA2
UNIPROT ID:   Q12891 (Gene Accession – BC000692 )
Background:    This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5′ UTR.
Immunogen:    Fusion protein of human HYAL2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human renal cancer tissue using 217524(HYAL2 Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human renal cancer tissue is first treated with the fusion protein and then with 217524(Anti-HYAL2 Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 217524(Anti-HYAL2 Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with fusion protein and then with D222520(Anti-HYAL2 Antibody) at dilution 1/40.
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