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MAP3K7 Rabbit pAb

Anti-MAP3K7 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217879

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217879
Product Name:   Anti-MAP3K7 Rabbit Polyclonal Antibody
Synonyms:   CSCF; FMD2; TAK1; MEKK7; TGF1a
UNIPROT ID:   O43318 (Gene Accession – BC017715 )
Background:    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Immunogen:    Fusion protein of human MAP3K7
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 200-300;WB: 500-2000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cardiovascular, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 217879(MAP3K7 Antibody) at a dilution of 1/150(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 217879(Anti-MAP3K7 Antibody) at dilution 1/150.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane 1-5: 231, 293T, HepG2, Jurkat and K562 cell lysates;
Primary antibody: 217879(MAP3K7 Antibody) at dilution 1/1000;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 1 minute
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