Email: info@neweastbio.com   |  Call: 6109452007

NSMCE2 Rabbit pAb

Anti-NSMCE2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218210

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218210
Product Name:   Anti-NSMCE2 Rabbit Polyclonal Antibody
Synonyms:   NSE2; MMS21; ZMIZ7; C8orf36
UNIPROT ID:   Q96MF7 (Gene Accession – BC032797 )
Background:    NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 comple,x a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRA,x and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Immunogen:    Full length fusion protein
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 218210(NSMCE2 Antibody) at a dilution of 1/25(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 218210(Anti-NSMCE2 Antibody) at dilution 1/25.
          Publications