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HLA-DPB1 Rabbit pAb

Anti-HLA-DPB1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218848

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218848
Product Name:   Anti-HLA-DPB1 Rabbit Polyclonal Antibody
Synonyms:   DPB1; HLA-DP; HLA-DPB; HLA-DP1B
UNIPROT ID:   P04440 (Gene Accession – BC015000 )
Background:    HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Immunogen:    Fusion protein of human HLA-DPB1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 40-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 218848(HLA-DPB1 Antibody) at a dilution of 1/45(Cytoplasm and Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the fusion protein and then with 218848(Anti-HLA-DPB1 Antibody) at dilution 1/45.
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