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FKBP1A Rabbit pAb

Anti-FKBP1A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218942

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218942
Product Name:   Anti-FKBP1A Rabbit Polyclonal Antibody
Synonyms:   FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A
UNIPROT ID:   P62942 (Gene Accession – BC005147 )
Background:    The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Immunogen:    Fusion protein of human FKBP1A
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 40-200;WB: 200-1000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 218942(FKBP1A Antibody) at a dilution of 1/55(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the fusion protein and then with 218942(Anti-FKBP1A Antibody) at dilution 1/55.

Gel: 12%SDS-PAGE, Lysate: 40 μg;
Lane 1-3: Mouse brain tissue, Human fetal brain tissue and Jurkat cell lysates;
Primary antibody: 218942(FKBP1A Antibody) at dilution 1/250;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 2 minutes
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