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SAV1 Rabbit pAb

Anti-SAV1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219368

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219368
Product Name:   Anti-SAV1 Rabbit Polyclonal Antibody
Synonyms:   SAV; WW45; WWP4
UNIPROT ID:   Q9H4B6 (Gene Accession – BC020537 )
Background:    WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Immunogen:    Fusion protein of human SAV1
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 100-300;WB: 500-2000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 219368(SAV1 Antibody) at a dilution of 1/90(Cytoplasm or Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the fusion protein and then with 219368(Anti-SAV1 Antibody) at dilution 1/90.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 219368(Anti-SAV1 Antibody) at a dilution of 1/90.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with fusion protein and then with D226556(Anti-SAV1 Antibody) at dilution 1/90.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane 1-2: HUVEC, PC-3 cell lysates;
Primary antibody: 219368(SAV1 Antibody) at dilution 1/800;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 1 minute
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