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GRB10 Rabbit pAb

Anti-GRB10 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219829

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219829
Product Name:   Anti-GRB10 Rabbit Polyclonal Antibody
Synonyms:   RSS, IRBP, MEG1, GRB-IR, Grb-10
UNIPROT ID:   Q13322 (Gene Accession – NP_005302 )
Background:    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.
Immunogen:    Synthetic peptide of human GRB10
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 219829(GRB10 Antibody) at a dilution of 1/25(Cytoplasm, Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 219829(Anti-GRB10 Antibody) at dilution 1/25.
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