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LRP6 Rabbit pAb

Anti-LRP6 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219896

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219896
Product Name:   Anti-LRP6 Rabbit Polyclonal Antibody
Synonyms:   ADCAD2
UNIPROT ID:   O75581 (Gene Accession – BC143725 )
Background:    This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Immunogen:    Synthetic peptide of human LRP6
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 40-200; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 219896(LRP6 Antibody) at a dilution of 1/60(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 219896(Anti-LRP6 Antibody) at dilution 1/60.
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