Email: info@neweastbio.com   |  Call: 6109452007

PTTG1 Rabbit pAb

Anti-PTTG1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219977

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219977
Product Name:   Anti-PTTG1 Rabbit Polyclonal Antibody
Synonyms:   EAP1; PTTG; HPTTG; TUTR1
UNIPROT ID:   O95997 (Gene Accession – NP_004210.1 )
Background:    The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
Immunogen:    Synthetic peptide of human PTTG1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 219977(PTTG1 Antibody) at a dilution of 1/30(Cytoplasm, Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 219977(Anti-PTTG1 Antibody) at dilution 1/30.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 219977(Anti-PTTG1 Antibody) at a dilution of 1/30.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D260722(Anti-PTTG1 Antibody) at dilution 1/30.
          Publications