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SOCS1 Rabbit pAb

Anti-SOCS1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219997

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219997
Product Name:   Anti-SOCS1 Rabbit Polyclonal Antibody
Synonyms:   JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1
UNIPROT ID:   O15524 (Gene Accession – NP_003736 )
Background:    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Immunogen:    Synthetic peptide of human SOCS1
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 100-300;WB: 1000-5000;ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 219997(SOCS1 Antibody) at a dilution of 1/90(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 219997(Anti-SOCS1 Antibody) at dilution 1/90.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 219997(Anti-SOCS1 Antibody) at a dilution of 1/90.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D260748(Anti-SOCS1 Antibody) at dilution 1/90.

Gel: 12%SDS-PAGE, Lysate: 40 μg;
Lane: 231 cell lysate;
Primary antibody: 219997(SOCS1 Antibody) at dilution 1/1700;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 5 minutes
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