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MYSM1 Rabbit pAb

Anti-MYSM1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220130

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220130
Product Name:   Anti-MYSM1 Rabbit Polyclonal Antibody
Synonyms:   2ADUB, 2A-DUB, RP4-592A1.1
UNIPROT ID:   Q5VVJ2 (Gene Accession – NP_001078956 )
Background:    Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Immunogen:    Synthetic peptide of human MYSM1
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 500-2000;ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 220130(MYSM1 Antibody) at a dilution of 1/60(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the synthetic peptide and then with 220130(Anti-MYSM1 Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 220130(Anti-MYSM1 Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with synthetic peptide and then with D261010(Anti-MYSM1 Antibody) at dilution 1/60.

Gel: 8%SDS-PAGE, Lysate: 50 μg;
Lane: Mouse kidney tissue;
Primary antibody: 220130(MYSM1 Antibody) at dilution 1/1100;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 40 seconds
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