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PDGFB Rabbit pAb

Anti-PDGFB Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220171

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220171
Product Name:   Anti-PDGFB Rabbit Polyclonal Antibody
Synonyms:   SIS, SSV, PDGF2, c-sis
UNIPROT ID:   P01127 (Gene Accession – NP_002599 )
Background:    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Immunogen:    Synthetic peptide of human PDGFB
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cancer, Cardiovascular, Metabolism, Developmental Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 220171(PDGFB Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 220171(Anti-PDGFB Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 220171(Anti-PDGFB Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D261079(Anti-PDGFB Antibody) at dilution 1/40.
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