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RBFOX1 Rabbit pAb

Anti-RBFOX1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220257

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220257
Product Name:   Anti-RBFOX1 Rabbit Polyclonal Antibody
Synonyms:   2BP1; FOX1; A2BP1; FOX-1; HRNBP1
UNIPROT ID:   Q9NWB1 (Gene Accession – NP_001135805 )
Background:    The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen:    Synthetic peptide of human RBFOX1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Neuroscience, Developmental Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 220257(RBFOX1 Antibody) at a dilution of 1/50(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 220257(Anti-RBFOX1 Antibody) at dilution 1/50.

The image on the left is immunohistochemistry of paraffin-embedded Human bladder cancer tissue using 220257(Anti-RBFOX1 Antibody) at a dilution of 1/50.

In comparision with the IHC on the left, the same paraffin-embedded Human bladder cancer tissue is first treated with synthetic peptide and then with D261214(Anti-RBFOX1 Antibody) at dilution 1/50.
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