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SRGAP1 Rabbit pAb

Anti-SRGAP1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220971

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220971
Product Name:   Anti-SRGAP1 Rabbit Polyclonal Antibody
Synonyms:   ARHGAP13
UNIPROT ID:   Q7Z6B7 (Gene Accession – NP_065813 )
Background:    SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner.
Immunogen:    Synthetic peptide of human SRGAP1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 220971(SRGAP1 Antibody) at a dilution of 1/35(Cytoplasm ).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 220971(Anti-SRGAP1 Antibody) at dilution 1/35.
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