NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: S221122 | ||||
Product Name: Anti-ENTPD1 (CD39) Rabbit Polyclonal Antibody | ||||
Synonyms: CD39; SPG64; ATPDase; NTPDase-1 | ||||
Target: CD39/ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1) | ||||
UNIPROT ID: P49961 (Gene Accession – NP_001767 ) | ||||
Background: CD39/ENTPD1 is the major ectonucleotidase expressed in macrophages. It hydrolyzes extracellular ATP and ADP to AMP. This enzyme plays an important immunomodulatory role on macrophages by regulating the extracellular ATP levels and limiting P2-mediated cellular responses, such as apoptosis, NLRP3 inflammasome activation, and IL-1β release. In neutrophil, impairment of nucleotide catabolism by pharmacologic inhibition or genetic deletion of CD39 increases the activation, chemotaxis, and adhesion of neutrophils to the vascular endothelium. In natural killer (NK) cells, a type of cytotoxic lymphocyte, which are also crucial to the innate immune responses, it is the dominant ectonucleotidase. CD39 activity in NK cells augments the capacity of these cells to secrete IFNγ by modulating P2 receptor activation. Thus, CD39 deletion on NK cells provides end-organ protection decreasing tissue damage mediated by NK cells. Finally, in dendritic cells (DCs) that are cells classically responsible for linking innate to adaptive immunity by capturing, processing, presenting antigens, and migrating to lymphoid tissues for the stimulation of antigen-reactive T cells, CD39 activity can regulate nucleotide levels, consequently, impair DCs’ responses. | ||||
Immunogen: Synthetic peptide of human ENTPD1 | ||||
Applications: ELISA, WB, IHC | ||||
Recommended Dilutions: IHC: 50-200;WB: 1000-5000;ELISA: 5000-10000 | ||||
Host Species: Rabbit | ||||
Clonality: Rabbit Polyclonal | ||||
Isotype: Immunogen-specific rabbit IgG | ||||
Purification: Antigen affinity purification | ||||
Species Reactivity: Human, Mouse, Rat | ||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||||
Research Areas: Immunology | ||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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