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CX3CR1 Rabbit pAb

Anti-CX3CR1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221321

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221321
Product Name:   Anti-CX3CR1 Rabbit Polyclonal Antibody
Synonyms:   V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1
Target:    CX3CR1 (C-X3-C motif chemokine receptor 1)
UNIPROT ID:   P49238 (Gene Accession – NP_001328 )
Background:     CX3C motif chemokine receptor 1 (CX3CR1) is known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13). It is a transmembrane protein of the G protein-coupled receptor 1 (GPCR1) family. The receptor binds the inflammatory chemokine CX3CL1 (also called neurotactin in mice or fractalkine in humans). This endogenous ligand solely binds to CX3CR1 receptor. Interaction of CX3CR1 with CX3CL1 can mediate migration, adhesion and retention of leukocytes, because Fractalkine exists as membrane-anchored protein (mCX3CL1) as well as cleaved soluble molecule (sCX3CL1) due to proteolysis by metalloproteinases (MPPs). The shredded form carries out typical function of conventional chemokines, the chemotaxis, while the membrane-bound protein behaves as adhesion molecule for facilitation of diapedesis.
Immunogen:    Synthetic peptide of human CX3CR1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing
Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 221321(CX3CR1 Antibody) at a dilution of 1/50(Cytoplasm). In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the synthetic peptide and then with 221321(Anti-CX3CR1 Antibody) at dilution 1/50.
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