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RIOX1 Rabbit pAb

Anti-RIOX1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221639

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221639
Product Name:   Anti-RIOX1 Rabbit Polyclonal Antibody
Synonyms:   ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
UNIPROT ID:   Q9H6W3 (Gene Accession – NP_078920 )
Background:    Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ‘Lys-4’ (H3K4me) and ‘Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ‘Lys-4’ (H3K4me3) and monomethylated H3 ‘Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ‘Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ‘His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Immunogen:    Synthetic peptide of human RIOX1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 221639(RIOX1 Antibody) at a dilution of 1/45(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 221639(Anti-RIOX1 Antibody) at dilution 1/45.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 221639(Anti-RIOX1 Antibody) at a dilution of 1/45.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D263324(Anti-RIOX1 Antibody) at dilution 1/45.
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