Email: info@neweastbio.com   |  Call: 6109452007

CASP10 Rabbit pAb

Anti-CASP10 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221843

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221843
Product Name:   Anti-CASP10 Rabbit Polyclonal Antibody
Synonyms:   MCH4; ALPS2; FLICE2
UNIPROT ID:   Q92851 (Gene Accession – NP_116756 )
Background:    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Immunogen:    Synthetic peptide of human CASP10
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 221843(CASP10 Antibody) at a dilution of 1/20(Cytoplasm and Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 221843(Anti-CASP10 Antibody) at dilution 1/20.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 221843(Anti-CASP10 Antibody) at a dilution of 1/20.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D263609(Anti-CASP10 Antibody) at dilution 1/20.
          Publications