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DNAJC8 Rabbit pAb

Anti-DNAJC8 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221905

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221905
Product Name:   Anti-DNAJC8 Rabbit Polyclonal Antibody
Synonyms:   SPF31; HSPC331
UNIPROT ID:   O75937 (Gene Accession – NP_055095 )
Background:    The DnaJ family is one of the largest of all chaperone families and has evolved with diverse cellular localization and functions. Presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are derived from Escherichia coli and are under the control of the htpR regulatory protein. DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins contain cysteine rich regions that are composed of zinc fingers, which form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJC8 (DnaJ (Hsp 40) homolog, subfamily C, member 8), also known as SPF31 or HSPC331, is a 253 amino acid protein that is suggested to have a potential role as a cochaperone in RNA processing-related processes.
Immunogen:    Synthetic peptide of human DNAJC8
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 221905(DNAJC8 Antibody) at a dilution of 1/25(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 221905(Anti-DNAJC8 Antibody) at dilution 1/25.
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