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IL4R Rabbit pAb

Anti-IL4R Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S222223

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S222223
Product Name:   Anti-IL4R Rabbit Polyclonal Antibody
Synonyms:   CD124; IL4RA; IL-4RA
UNIPROT ID:   P24394 (Gene Accession – NP_000409 )
Background:    This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Immunogen:    Synthetic peptide of human IL4R
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 222223(IL4R Antibody) at a dilution of 1/45(Cytoplasm ).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 222223(Anti-IL4R Antibody) at dilution 1/45.

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using 222223(Anti-IL4R Antibody) at a dilution of 1/45.

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with synthetic peptide and then with D264246(Anti-IL4R Antibody) at dilution 1/45.
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