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JNK1 (1A4) Mouse mAb

Anti-JNK1 (1A4) Mouse Monoclonal Antibody
5/5

$349.00

Cat.#:  N261122

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261122
Product Name:   Anti-JNK1 (1A4) Mouse Monoclonal Antibody
Synonyms:   AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase; mitogen-activated; 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 .
UNIPROT ID:   P45983
Background:    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Immunogen:    Purified recombinant human JNK1 protein fragments expressed in E.coli.
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Mouse
Clonality:    Mouse Monoclonal
Clone ID:    1A4-C5-F11
MW:    Calculated MW: 48 kDa; Observed MW: 46,54 kDa
Isotype:    IgG2a
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunofluorescence analysis of JNK1 (1A4) in 3T3 using JNK1 antibody.

Western blot analysis of JNK1 in C6 and 3T3 lysates using JNK1 antibody.

Western blot analysis of JNK1 (1A4) in CHO-K1 cell lysates(B) and CHO-K1 transfected by JNK1fragment fusion protein(A) cell lysates using JNK1 antibody.
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